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2007 1
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146 results

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Page 1
CARD9 Signaling, Inflammation, and Diseases.
Liu X, Jiang B, Hao H, Liu Z. Liu X, et al. Front Immunol. 2022 Mar 30;13:880879. doi: 10.3389/fimmu.2022.880879. eCollection 2022. Front Immunol. 2022. PMID: 35432375 Free PMC article. Review.
Caspase-recruitment domain 9 (CARD9) protein is expressed in many cells especially in immune cells, and is critically involved in the function of the innate and adaptive immune systems through extensive interactions between CARD9 and other signaling molecules includ …
Caspase-recruitment domain 9 (CARD9) protein is expressed in many cells especially in immune cells, and is critically involved in the …
CARD9 in neutrophils protects from colitis and controls mitochondrial metabolism and cell survival.
Danne C, Michaudel C, Skerniskyte J, Planchais J, Magniez A, Agus A, Michel ML, Lamas B, Da Costa G, Spatz M, Oeuvray C, Galbert C, Poirier M, Wang Y, Lapière A, Rolhion N, Ledent T, Pionneau C, Chardonnet S, Bellvert F, Cahoreau E, Rocher A, Arguello RR, Peyssonnaux C, Louis S, Richard ML, Langella P, El-Benna J, Marteyn B, Sokol H. Danne C, et al. Gut. 2023 Jun;72(6):1081-1092. doi: 10.1136/gutjnl-2022-326917. Epub 2022 Sep 27. Gut. 2023. PMID: 36167663 Free article.
OBJECTIVES: Inflammatory bowel disease (IBD) results from a combination of genetic predisposition, dysbiosis of the gut microbiota and environmental factors, leading to alterations in the gastrointestinal immune response and chronic inflammation. Caspase recruitment domain …
OBJECTIVES: Inflammatory bowel disease (IBD) results from a combination of genetic predisposition, dysbiosis of the gut microbiota and envir …
Neutrophils: from IBD to the gut microbiota.
Danne C, Skerniskyte J, Marteyn B, Sokol H. Danne C, et al. Nat Rev Gastroenterol Hepatol. 2024 Mar;21(3):184-197. doi: 10.1038/s41575-023-00871-3. Epub 2023 Dec 18. Nat Rev Gastroenterol Hepatol. 2024. PMID: 38110547 Review.
Numerous IBD susceptibility genes (such as NOD2, NCF4, LRRK2, CARD9) are involved in neutrophil functions related to defence against microorganisms. ...This observation demonstrates the dialogue between neutrophils, gut inflammation and the microbiota. Neutrophils a …
Numerous IBD susceptibility genes (such as NOD2, NCF4, LRRK2, CARD9) are involved in neutrophil functions related to defence against …
CARD9 Regulation and its Role in Cardiovascular Diseases.
Zhang H, Wang Y, Men H, Zhou W, Zhou S, Liu Q, Cai L. Zhang H, et al. Int J Biol Sci. 2022 Jan 1;18(3):970-982. doi: 10.7150/ijbs.65979. eCollection 2022. Int J Biol Sci. 2022. PMID: 35173530 Free PMC article. Review.
Here, we summarize the structure and function of CARD9 in innate immunity and its various roles in inflammation, apoptosis, and autophagy in the pathogenesis of CVDs. Furthermore, we discuss the potential therapies targeting CARD9 to prevent CVDs and raise so …
Here, we summarize the structure and function of CARD9 in innate immunity and its various roles in inflammation, apoptosis, an …
The role of the CBM complex in allergic inflammation and disease.
DeVore SB, Khurana Hershey GK. DeVore SB, et al. J Allergy Clin Immunol. 2022 Nov;150(5):1011-1030. doi: 10.1016/j.jaci.2022.06.023. Epub 2022 Aug 16. J Allergy Clin Immunol. 2022. PMID: 35981904 Free PMC article. Review.
The caspase activation and recruitment domain-coiled-coil (CARD-CC) family of proteins-CARD9, CARD10, CARD11, and CARD14-is collectively expressed across nearly all tissues of the body and is a crucial mediator of immunologic signaling as part of the CARD-B-cell lymphoma/l …
The caspase activation and recruitment domain-coiled-coil (CARD-CC) family of proteins-CARD9, CARD10, CARD11, and CARD14-is collectiv …
The role and mechanism of CARD9 gene polymorphism in diseases.
Ji C, Yang Z, Zhong X, Xia J. Ji C, et al. Biomed J. 2021 Oct;44(5):560-566. doi: 10.1016/j.bj.2020.12.006. Epub 2020 Dec 30. Biomed J. 2021. PMID: 34690098 Free PMC article. Review.
In addition, CARD9 polymorphisms show a defective neutrophil accumulation in infectious sites. Furthermore, CARD9 polymorphisms could alter the composition of the gut microbiome. ...
In addition, CARD9 polymorphisms show a defective neutrophil accumulation in infectious sites. Furthermore, CARD9 polymorphism …
CARD9, VAV3, and infection risk in IgA nephropathy.
Gleeson PJ, Sokol H, Monteiro RC. Gleeson PJ, et al. Kidney Int. 2023 May;103(5):996-997. doi: 10.1016/j.kint.2023.02.013. Kidney Int. 2023. PMID: 37085264 No abstract available.
The essential function of CARD9 in diet-induced inflammation and metabolic disorders in mice.
Zeng X, Du X, Zhang J, Jiang S, Liu J, Xie Y, Shan W, He G, Sun Q, Zhao J. Zeng X, et al. J Cell Mol Med. 2018 Jun;22(6):2993-3004. doi: 10.1111/jcmm.13494. Epub 2018 Mar 25. J Cell Mol Med. 2018. PMID: 29575791 Free PMC article.
The results showed that HFD-induced insulin resistance and impairment of glucose tolerance were more severe in WT mice than that in the CARD9(-/-) mice. CARD9 absence significantly modified O(2) consumption, CO(2) production and heat production. ...HFD induced the i …
The results showed that HFD-induced insulin resistance and impairment of glucose tolerance were more severe in WT mice than that in the C …
CARD9 Signaling in Intestinal Immune Homeostasis and Oncogenesis.
Hartjes L, Ruland J. Hartjes L, et al. Front Immunol. 2019 Mar 11;10:419. doi: 10.3389/fimmu.2019.00419. eCollection 2019. Front Immunol. 2019. PMID: 30906296 Free PMC article. Review.
Moreover, polymorphisms in CARD9 are key risk factors for IBD development, indicating that CARD9 signaling is critical for intestinal immune homeostasis. This review summarizes recent insights into the regulation of CARD9 signaling, its pathophysiological rol …
Moreover, polymorphisms in CARD9 are key risk factors for IBD development, indicating that CARD9 signaling is critical for int …
146 results